Clinical efficacy of EPIGEN in the management of female herpes genitalis.

• Medical Team
  Doschanova A. M.
  Kazakh Medical State University
  Almaty / KAZAKHSTAN
  
  
• Preliminary
  TREATMENT OF GENITAL HERPES WITH EPIGEN AS AN ANTIVIRAL
  Number of patients: 22
  Age: from 21 to 38 years
  Analysis: PCR
  Dosage: 6 (six) times per day
  Duration of treatment: 5 - 7 days
  Follow-up: 7 - 10 days
  Long-dated check-ups: monthly controls for six months
  

  
  
• Results
  • The findings of the performed clinical trials show a high efficacy of EPIGEN in the management of herpetic infections. 20 patients stopped complaining about itching and intense burning on the second day of the therapy, and the two remaining patients, on the third day.
  
  • Re-examination one month after therapy with EPIGEN revealed the total absence of herpes simplex virus in 10 patients, and six months after therapy, in another 5 females.
  
  • No allergic reactions or side effects were reported.
  
  
• Conclusions
  EPIGEN is a preparation of high efficacy for topical use in the treatment of herpetic infections. It is practical and tolerable. Without side effects and with quick absorption.
  
  This preparation can be recommended for wide use in the medical practice.
  
  
• Other uses
  • Management of lichen shingles caused by varicella-zoster virus.

  • Therapy for cytomegalovirus infection.

  • Management of papilloma virus and infections caused by different types (included oncogenic ones) of the mentioned human virus.

  • Therapies for vaginosis, colpitis and vaginal microflora in general, confirming its normalization.

  • As a prophylactic antiviral and anti-inflammatory preparation in sexual intercourse.

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herpesvirus

female genital herpes

Clinical trial report on the efficacy of EPIGEN spray in the complex management of vaginal candidiasis in pregnant women.

• Medical Team
  Dr. Saparbekova A. Z.
  (supervision of Prof. Mamedalieva N. M.)
  Republican Scientific Research Centre of Maternal and Infantile Health Care
  Almaty / KAZAKHSTAN

  October 16, 2001

• Preliminary
  • Treatment of gestational vaginal candidiasis is urgent, since this type of candidiasis is twice as frequent, making up 30 - 40 % according to various authors. This disease is known to be a leading reason for severe gestational complications.

  • Miscarriage and pregnancy termination incidence increases by 1.5 times; foetal and neonatal infection by 2.4 times. Therefore, timely diagnosis and management of vaginal candidiasis is especially urgent in pregnancy. Said management is complicated by the need of excluding negative effects of the preparation on the foetus.

  • The efficacy of EPIGEN Spray in these complex treatments of gestational vaginal candidiasis was clinically tested at the Republican Scientific Research Centre of Maternal and Infantile Health Care.

• Properties of Glycyrrhizinic Acid
  • Glycyrrhizinic acid - which is contained in EPIGEN - is an active agent with marked antiviral, anti-inflammatory, antipruritic, interferonogenic and immunomodulating effects.

  • Glycyrrhizinic acid induces the formation of interferon, inhibits the activity of phospholipase A and the formation of prostaglandin E2 and stimulates the mechanisms of phagocytosis. The anti-inflammatory activity of glycyrrhizinic acid goes with the stimulating effect on humoral and cellular factors of immunity. The antibacterial effect of glycyrrhizinic acid was observed on the flora that conditions pathogeneity. It inhibits lipid peroxidation by binding free radicals and toxic oxidation products.

  • Glycyrrhizinic acid contributes as well to the normalization of the vaginal microflora.

• Conclusions
  EPIGEN Spray can be recommended for local immunostimulation in the complex management of gestational vaginal infections.

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vaginal candidiasis

candida albicans

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Efficacy of EPIGEN in the complex treatment of women with bacterial vaginosis.

• Medical Team
  Abidov A. M., Faizieva G. B., Turdyeva E. Sh., Ybaidullaev Z. Kh. and Razykov A. A.
  Scientific Research Institute of Dermatology
  and Venerology MINISTRY OF PUBLIC HEALTH
  Republic of Uzbekistan
  
• Preliminary
  • Bacterial vaginosis is a disease caused by an imbalance in the vaginal microflora, characterized by the increase of anaerobes and the decrease of lactobacilli.

  • Bacterial vaginosis presents considerable difficulties to treatment. The products normally used are inefficient for the reduction of the recurrence rate.

  • EPIGEN Spray contains glycyrrhizinic acid activated by physical-chemical methods as the main active agent.

  Number of patients: 16 women
  Age: from 19 to 25 years
  Duration of disease: from 3 months to 2 years
  Dosage: 3 - 4 times per day for 7 - 10 days

• Conclusions
  • The preparation EPIGEN is practical, tolerable and does not cause side effects.

  • It responded with efficacy in the complex treatment of bacterial vaginosis and can be recommended for its therapy.

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bacterial vaginosis

bacterial vaginosis

Glycyrrhizinic acid (EPIGEN) as an Additional Topical Treatment of Mucous Lesions in PEMPHIGUS.

• Medical Team
  Svecová D., Zelenková H.
  Dept. of Dermatovenerology, Faculty of Medicine, Comenius University, Bratislava / SLOVAK REPUBLIC
  1DOST Dept. of Dermatovenerology.
  Svidnik / SLOVAK REPUBLIC
  
• Background
  The treatment of pemphigus vulgaris involves the use of systemic immunosuppressive agents. Topical treatment is only additional treatment, but it is important because of the possibility to modify the decrease of immunosuppressive drugs.
  
• Objectives
  Glycyirrhiza glabra (licorice) is well-known and used in traditional medicine. Glycyrrhizinic acid (EPIGEN, from Cheminova Internacional, S.A.) is an effective substance and it has been proposed as an antiviral agent. Because of the anti-inflammatory and immunomodulatory effects, we used it as an additional topical treatment in patients with pemphigus to support the healing of the disease.

• Methods
  Fourteen subjects suffering from mucous lesions of pemphigus (11 females, 3 males, average age 46.07 years) were treated with the topical administration of glycirrhizinic acid. They received treatment 2 - 3 times per day. All subjects were under oral administration of immunosuppressive agents.

• Results
  The treatment was administered for 9 – 28 days. In 7 subjects, the lesions were completely healed (50%); in 4 subjects, there was a considerable clinical improvement (28.57%) and in 3 subjects, there was a clinical improvement (21.42%). The treatment was well tolerated by all subjects and there were no adverse effects.

• Conclusion
• This study showed a new additional topical treatment for pemphigus vulgaris.
• Glycyrrhizinic acid, with its to the anti-inflammatory and immunomodulatory effects, improves the mucous lesions and reams out the possibility of the topical treatment of bullous disorders.

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pemphigus vulgaris at the beginning	after 18 days of treatment
pemphigus vulgaris at the beginning	after 14 days of treatment

The use of preparations containing Glycyrhizinic Acid (EPIGEN) in the dermatological practice.

• Medical Team
  Hana Zelenková
  Dept. of Dermatovenerology, Svidnik / SLOVAK REPUBLIC
  Alena Nejdková
  Privat dermatovenerology outpatient department, Îilina / SLOVAK REPUBLIC
  Eva Skutilová
  Privat dermatovenerology outpatient department, Podunajské Biskupice / SLOVAK REPUBLIC
  Milan Urbáni
  Dept. of Dermatology, Faculty Hospital, Banská Bystrica / SLOVAK REPUBLIC
  Danka Svecová
  Dept. of Dermatology, Faculty Hospital, Bratislava / SLOVAK REPUBLIC
  Jirina Cabalová, Privat dermatovenerology outpatient department, Praha / SLOVAK REPUBLIC
  SLOVAK REPUBLIC
  
  Glycyrrhizinic acid interacts with virus structures (proteins), producing different effects that depend on the affected viral stage:
  • Inactivation of free extracellular virus particles.
  • Prevention of intracellular uncoating of infecting particles.
  • Impairment of the assembling ability of structural virus components.
  • The anti-inflammatory effect of glycyrrrhizinic acid (GL) has been well known already in the traditional Chinese medicine.
  • The first studies on the effects of GL were performed in 1979 - Doll et al., Pompei, Flore et al.
  • The most frequent and most extensive studies were performed by Japanese authors.
  The development of the preparation EPIGEN (Cheminova Internacional, S.A.) was based on the evaluation of latest current results of scientific research.
  The preparation developed according to this knowledge fulfils the attributes of absolute safety and maximum efficacy.
  The preparation has been applied during a multicenter study in 55 patients (herpes simplex, herpes genitalis, herpes zoster, condylomata accuminata, verucae vulgares pemphigus vulgaris, Morbus Hailey-Hailey).
  
• Conclusions
  The therapeutic effect of the preparation was very good. Undesirable effects were observed only exceptionally.
  The preparation may be administered also during pregnancy. Numerous clinical studies with EPIGEN demonstrated its effectiveness in more than 90 % of the cases. The preparation is highly effective in the treatment of initial and recurrent viral infections. Therapeutically interesting is also its application for the treatment of bullous dermatoses.

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Tables and Charts
Clinical Photographics

condyloma acuminata at the beginning	after 15 days of treatment
herpes simplex permagnus at the beginning	after therapy

Download the original article "Rev Hosp Gral Dr. M Gea Gónzalez 2000;3(4):141-144" in “pdf” format.

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